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Publications

306, 2018

YH25448, a 3rd Generation EGFR-TKI, in Patients with EGFR-TKI-resistant NSCLC: Phase I/II Study Results

By | June 3rd, 2018|

Genosco's pipeline GNS-1480 (YH25448) was presented at ASCO 2018. *ASCO stands for American Society of Clinical Oncology Annual Meeting.

1605, 2018

YH25448, a 3rd generation EGFR-TKI, in patients with EGFR-TKI-resistant NSCLC: Phase I/II study results

By | May 16th, 2018|

ASCO 2018 Poster Board: #356 • Abstract 9033; Byoung Chul Cho - First Author, Severence Hospital

1804, 2018

YH25448, an irreversible 3rd-generation EGFR TKI, exhibits superior anticancer effects with potent brain BBB penetration in NSCLC

By | April 18th, 2018|

Genosco's pipeline GNS-1480 (YH25448) was presented at AACR Annual meeting 2018. *AACR stands for American Association for Cancer Research.

1602, 2017

Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer

By | February 16th, 2017|

This article was published on Cancer Research - AACR Journals, doi: 10.1158/0008-5472.CAN-16-2432 in February 2017.

712, 2016

YH25448, a highly selective 3rd generation EGFR TKI, exhibits superior survival benefit over osimertinib in mice with brain metastases of NSCLC

By | December 7th, 2016|

Genosco's pipeline GNS-1480 (Yuhan code: YH25448) was presented at the IASLC 17th World Conference on Lung Cancer in December 2016. ​ *IASLC stands for International Association for the Study of Lung Cancer.

110, 2016

Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs

By | October 1st, 2016|

This article was published in The FEBS Journal, Volume 238, Issue 19, Pages 3613-3625 in October 2016.

1510, 2015

Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors

By | October 15th, 2015|

This article was published in Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 20, Pages 4441-4446 in October 2015. ​ It was also featured in World Biomedical Frontiers.

304, 2014

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia

By | April 3rd, 2014|

This article was published in Blood, Volume 123, Number 14, Pages 2209-2219 in April 2014. ​ It was also published in SciBX, Volume 7, Number 12 in March 2014.

3107, 2013

Crystal Structure of Pim1 Kinase in Complex with a Pyrido[4,3-D]Pyrimidine Derivative Suggests a Unique Binding Mode

By | July 31st, 2013|

This article was published on PLoS ONE 8(7): e70358. doi: 10.1371/journal.pone.0070358 in July 2013.