SYK
SKI-O-703
– Selective SYK inhibitor for autoimmune disorders
– Proposed indications of SKI-O-703 include rheumatoid arthritis (RA), immune thrombocytopenia (ITP), systemic lupus erythematosus(SLE), autoimmune hemolytic anemia (AIHA) and IgA nephropathy (IgAN), as well as indications such as atopic dermatitis, asthma, allergies, and psoriasis.
– Selective SYK inhibitor for autoimmune disorders
– Proposed indications of SKI-O-703 include rheumatoid arthritis (RA), immune thrombocytopenia (ITP), systemic lupus erythematosus(SLE), autoimmune hemolytic anemia (AIHA) and IgA nephropathy (IgAN), as well as indications such as atopic dermatitis, asthma, allergies, and psoriasis.
FLT3
SKI-G-801
- Intravenous selective FLT3 inhibitor for acute myeloid leukemia
- SKI-G-801 is a highly potent and selective inhibitor against all clinically-known mutations in FLT3. Its superiority compared to any known FLT3 inhibitors
- Intravenous selective FLT3 inhibitor for acute myeloid leukemia
- SKI-G-801 is a highly potent and selective inhibitor against all clinically-known mutations in FLT3. Its superiority compared to any known FLT3 inhibitors
EGFR
GNS-1480 (YH25448)
– Oral 3rd-generation EGFR inhibitor for non-small cell lung cancer (NSCLC)
– Targeting various single and double mutants of EGFR including T790M/L858R and T790M/Del19
– Oral 3rd-generation EGFR inhibitor for non-small cell lung cancer (NSCLC)
– Targeting various single and double mutants of EGFR including T790M/L858R and T790M/Del19
4th–generation EGFR inhibitor program
– Targeting additional mutation of EGFR at amino acid position 797 (C797S), which is a main reason for drug resistance for 3rd generation EGFR inhibitors including Osmertinib®
Press Release
Genosco/Yuhan Announce Results from Phase 1/2 Study of YH25448, a 3rd-Generation EGFR-TKI, in Advanced NSCLC to be Presented at ASCO 2018
Business Wire * May 16, 2018;
Abstract – https://meetinglibrary.asco.org/record/161036/abstract
Current Partners
