OUR SCIENCE
We generate selective compounds leveraging
our proprietary G-SMART™ platform
Our Science
G-SMART™ Platform
As protein kinases share high sequence and structural similarity,
achieving high levels of selectivity for target kinase is crucial for successful new kinase-based drug development.
Our proprietary G-SMART™ platform enables discovery and optimization based on
rare sequences in protein kinases that can be targeted to develop a highly selective compound.
RARE
SEQUENCE
SEQUENCE
Mapping / profiling of
ATP binding sites of
kinases
ATP binding sites of
kinases
Large proprietary
chemical library of
master scaffolds
chemical library of
master scaffolds
Predictive modelling / structural analyses
*Rare sequence refers to a unique pattern of amino acids that are present only in the target kinase or
in a low frequency of all kinases, and therefore can be leveraged to achieve high selectivity
in a low frequency of all kinases, and therefore can be leveraged to achieve high selectivity
The G-SMART™ platform consists of the following
-
01.Deep statistical database of the mapping / profiling of ATP binding sites of human kinases
-
02.Large proprietary chemical library of 3,500+ master scaffolds that can readily be screened once a target has been identified and validated
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03.Various predictive modelling / structural analyses to discover, model and test compounds for further development
